Scientific Articles

Assessment of Therapeutic Effect of Intra-Articular Nanofat Injection for Temporomandibular Disorders

Posted in Clinical Trials & Pilot Studies, Craniofacial, Ideas & Innovations, Orthopedics, TMJ

Date Published: May/June 2019 Mahmmood et al. report that intra‑articular nanofat injection in patients with temporomandibular disorders was safe, well‑tolerated, suggesting therapeutic benefit as a minimally invasive treatment option. The article was published in the Journal of Craniofacial Surgery.

Can nano-fat injection in patients with tempromandibular disorder alters salivary matrix metalloproteinases 2 and 9?

Posted in Clinical Trials & Pilot Studies, Craniofacial, Ideas & Innovations, Orthopedics, TMJ

Date Published: 10 January 2024 Jafar & Hadi report that nano‑fat injections in patients with temporomandibular disorder significantly reduce salivary matrix metalloproteinases 2 and 9 levels, suggesting a potential therapeutic effect on extracellular matrix remodeling in TMD. The article was published in the Multidisciplinary Science Journal.

Intra-Articular Injection of Adipose-Derived Stromal Vascular Fraction in Osteoarthritic Temporomandibular Joints: Study Design of a Randomized Controlled Clinical Trial

Posted in Clinical Trials & Pilot Studies, General Orthopedics, Ideas & Innovations, Orthopedics, TMJ

Date Published: 10 February 2024 Schipper et al. investigate intra-articular injection of adipose-derived stromal vascular fraction for osteoarthritic temporomandibular joints, aiming to evaluate its safety and efficacy as a regenerative treatment approach. The article was published in Bioengineering.

Clarification of the Concept of “Regeneration” in the Context of Calcium Hydroxylapatite and Its Promotion in Regenerative Aesthetics

Posted in Aesthetic Dermatology (Facial Volume Restoration), Facial Rejuvenation & Skin Quality, Facial Volume Restoration, Ideas & Innovations, Latest News, Skin Rejuvenation

Date Published: 22 October 2025 Tonnard, Verpaele, & Romero discuss the use of the term regeneration in aesthetic medicine, emphasizing that treatments like Calcium Hydroxylapatite primarily promote tissue remodeling rather than true biological regeneration and highlight the need for more precise terminology in the field. The article was published in the Aesthetic Surgery Journal.

Ocular Complications Following Autologous Fat Injections into Facial Area: Case Report of a Recovery from Visual Loss After Ophthalmic Artery Occlusion and a Review of the Literature

Posted in Aesthetic Dermatology (Facial Volume Restoration), Clinical Trials & Pilot Studies, Dermatology, Facial Surgery, Facial Volume Restoration, Office Based Aesthetic Medicine, Periorbital Rejuvenation, Plastic Surgery

Date Published: 23 February 2017 Szantyr, et al. present the first report of recovery from vision loss caused by ophthalmic artery occlusion following autologous fat injection. They discuss the importance of awareness of this complication and need for popularizing the treatment method to prevent such consequences. The article was published in the Aesthetic Plastic Surgery Journal.

Complications of facial autologous fat grafting

Posted in Facial Surgery, Facial Volume Restoration, Latest News, Plastic Surgery, Techniques & Methods, Techniques & Methods for Fat Harvesting, Processing & Grafting

Date Published: 2 February 2024 Brown et al. review possible risk factors for adverse events associated with autologous fat grafting, investigate surgical techniques to mitigate these risks, and look into potential treatment options for complications of the procedure. The article was published in the Plastic and Aesthetic Research.

Fat embolism syndrome: a review in cosmetic surgery

Posted in Facial Surgery, Facial Volume Restoration, Ideas & Innovations, Latest News, Office Based Aesthetic Medicine, Plastic Surgery, Techniques & Methods for Fat Harvesting, Processing & Grafting

Date Published: 30 August 2024 Kim, et al. investigate fat embolism syndrome, an associated side effect of liposuction and fat grafting procedures, and identify effective treatment options based on the subtypes of this condition. The article was published in the Kosin Medical Journal.

Autologous Fat Grafting for Facial Rejuvenation

Posted in Aesthetic Dermatology (Facial Volume Restoration), Dermatology, Facial Rejuvenation & Skin Quality, Facial Volume Restoration, Office Based Aesthetic Medicine, Perioral Rejuvenation, Periorbital Rejuvenation, Techniques & Methods, Techniques & Methods for Fat Harvesting, Processing & Grafting

Date Published: 31 Jul 2023 Vasavada et al. provide a review of an autologous fat grafting procedure for facial rejuvenation. They discuss indications, equipment needed, techniques, and outcomes. The article was published in StatPearls [Internet].

The Effectiveness of Nanofat in the Management of Skin Scars: A Systematic Review

Posted in Dermatology, Facial Rejuvenation & Skin Quality, Office Based Aesthetic Medicine, Scar Treatment, Skin Scars & Acne Scarring

Date Published: 2 July 2025 Al-Sabri et al. conducted a systematic review to assess the effectiveness of Nanofat in treating various skin scars. Their findings suggest that Nanofat injections offer a minimally invasive and effective treatment option. The article was published in the Aesthetic Surgery Journal.

The Regenerative Marriage Between High-Density Platelet-Rich Plasma and Adipose Tissue

Posted in AD-cSVF, AD-tSVF, AD-MSC, Basic Science & Research, Ideas & Innovations, Latest News, PRP & Adipose, Regenerative Potential & Mechanisms of Nanofat, Wound Healing

Date Published: 27 February 2025 Everts et al., investigate the synergistic effects of combining HD-PRP with adipose tissue, particularly looking at the role of t-SVF in these effects. They find that the combination multicellular approach using both of these cellular biological products leads to improved tissue repair, regeneration and, wound healing. The article was published […]

Is Patient Demand for Cellular Therapies Real?

Posted in Blog

A Personal Message from the Founder Having worked closely with practitioners across specialties for over three decades, I understand your skepticism. When physicians first explore regenerative therapies, they often ask: “Is the patient demand actually real, or just marketing hype?” After years collecting data from hundreds of practices, the evidence is undeniable—patients are actively seeking […]

Autologous lipoaspirate as a new treatment of vulvar lichen sclerosus: A review on literature

Posted in Clinical Trials & Pilot Studies, Gynecology & Female Sexual Wellness, Ideas & Innovations

Date Published: 11 March 2022 Nanouk van der Sluis et al., complete a review of pioneering studies already done to investigate the therapeutic effect of adipose tissue grafting for Lichen Sclerosus. In this review, they provide an overview of these studies and the proposed mechanisms-of-action of using fat grafting to treat LS. The article was published […]