Category: Clinical Trials & Pilot Studies

Effects of Nanofat and PRP on Type I Collagen Production in Striae Distensae: Preliminary Findings from a Prospective, Randomized Single-Blind Study

Posted in Breast, Buttock, Clinical Trials & Pilot Studies, Dermatology, Facial Rejuvenation & Skin Quality, Ideas & Innovations, Office Based Aesthetic Medicine, Plastic Surgery, Scar Treatment, Skin Scars & Acne Scarring

Date Published: 03 December 2024 La Padula et al. evaluate the effects of nanofat and platelet-rich plasma on type I collagen production in striae distensae, demonstrating enhanced collagen synthesis and suggesting their potential as regenerative treatment options. The article was published in the Aesthetic Plastic Surgery Journal.

Minimally Invasive, Micro-Autologous Fat Transfer for Secondary Occipital Neuralgia

Posted in Clinical Trials & Pilot Studies, Ideas & Innovations, Pain Management

Date Published: 31 October 2025 Pietramaggiori, Peled, et al. evaluate minimally invasive micro-autologous fat transfer for secondary occipital neuralgia, demonstrating improvement in pain symptoms while supporting its potential as a safe and effective treatment option. The article was published in Pain Practice.

Can the Autogenous Nanofat Injection Improve the Symptoms of Patients With Temporomandibular Joint Internal Derangement? A Prospective Observational Clinical Study

Posted in Clinical Trials & Pilot Studies, Craniofacial, Ideas & Innovations, Orthopedics, Plastic Surgery, TMJ

Date Published: 13 Nov 2023 Ali et al. evaluate the effectiveness of intra-articular nanofat injection for temporomandibular joint internal derangement, demonstrating improvements in pain, mouth opening, and joint sounds while supporting its potential as a minimally invasive treatment option. The article was published in the The Journal of Craniofacial Surgery.

Assessment of Therapeutic Effect of Intra-Articular Nanofat Injection for Temporomandibular Disorders

Posted in Clinical Trials & Pilot Studies, Craniofacial, Ideas & Innovations, Orthopedics, TMJ

Date Published: May/June 2019 Mahmmood et al. report that intra‑articular nanofat injection in patients with temporomandibular disorders was safe, well‑tolerated, suggesting therapeutic benefit as a minimally invasive treatment option. The article was published in the Journal of Craniofacial Surgery.

Can nano-fat injection in patients with tempromandibular disorder alters salivary matrix metalloproteinases 2 and 9?

Posted in Clinical Trials & Pilot Studies, Craniofacial, Ideas & Innovations, Orthopedics, TMJ

Date Published: 10 January 2024 Jafar & Hadi report that nano‑fat injections in patients with temporomandibular disorder significantly reduce salivary matrix metalloproteinases 2 and 9 levels, suggesting a potential therapeutic effect on extracellular matrix remodeling in TMD. The article was published in the Multidisciplinary Science Journal.

Intra-Articular Injection of Adipose-Derived Stromal Vascular Fraction in Osteoarthritic Temporomandibular Joints: Study Design of a Randomized Controlled Clinical Trial

Posted in Clinical Trials & Pilot Studies, General Orthopedics, Ideas & Innovations, Orthopedics, TMJ

Date Published: 10 February 2024 Schipper et al. investigate intra-articular injection of adipose-derived stromal vascular fraction for osteoarthritic temporomandibular joints, aiming to evaluate its safety and efficacy as a regenerative treatment approach. The article was published in Bioengineering.

Ocular Complications Following Autologous Fat Injections into Facial Area: Case Report of a Recovery from Visual Loss After Ophthalmic Artery Occlusion and a Review of the Literature

Posted in Aesthetic Dermatology (Facial Volume Restoration), Clinical Trials & Pilot Studies, Dermatology, Facial Surgery, Facial Volume Restoration, Office Based Aesthetic Medicine, Periorbital Rejuvenation, Plastic Surgery

Date Published: 23 February 2017 Szantyr, et al. present the first report of recovery from vision loss caused by ophthalmic artery occlusion following autologous fat injection. They discuss the importance of awareness of this complication and need for popularizing the treatment method to prevent such consequences. The article was published in the Aesthetic Plastic Surgery Journal.

Autologous lipoaspirate as a new treatment of vulvar lichen sclerosus: A review on literature

Posted in Clinical Trials & Pilot Studies, Gynecology & Female Sexual Wellness, Ideas & Innovations

Date Published: 11 March 2022 Nanouk van der Sluis et al., complete a review of pioneering studies already done to investigate the therapeutic effect of adipose tissue grafting for Lichen Sclerosus. In this review, they provide an overview of these studies and the proposed mechanisms-of-action of using fat grafting to treat LS. The article was published […]

The Influence of Fat Grafting on Skin Quality in Cosmetic Foot Grafting: A Randomized, Cross-Over Clinical Trial

Posted in Clinical Trials & Pilot Studies, Dermatology, Foot & Ankle, Foot Fat Pad, Orthopedics, Skin Rejuvenation, Sports Medicine

Date Published: 10 July 2018 Stephanie E. Farber, et al., conducted a clinical trial with results indicating that pedal fat grafting resulted in a clinically significant and sustained increase in dermal thickness, as well as an improvement in skin quality. The article was published in Aesthetic Surgery Journal.

A New Minimally Invasive Procedure for Treating Plantar Heel Pain – Stromal Vascular Fraction Gel Grafting

Posted in Clinical Trials & Pilot Studies, Foot & Ankle, Foot Fat Pad, Orthopedics, Pain Management, Sports Medicine

Date Published: 5 Nov 2023 Bihua Wu, et al., investigated and found that stromal vascular fraction gel grafting is a safe, effective, and minimally invasive approach to treating plantar heel pain that actually worked to increase the thickness of the heel fat pad. The article was published in Annals of Plastic Surgery.

Autologous Nanofat Injection Combined with Fractional CO2 Laser in the Treatment of Atrophic Acne Scars

Posted in Clinical Trials & Pilot Studies, Combination with Energy Based Devices, Dermatology, Facial Rejuvenation & Skin Quality, Office Based Aesthetic Medicine, Scar Treatment, Skin Scars & Acne Scarring

Date Published: 20 Mar 2024 Mahmoud A Rageh, et al. investigate the role of Nanofat in combination with fractional CO2 laser as a combined approach for treating atrophic acne scarring. The article was published in Clinical, Cosmetic and Investigational Dermatology.

Nanofat Grafting: Basic Research and Clinical Applications

Posted in Clinical Trials & Pilot Studies, Dermatology, Facial Rejuvenation & Skin Quality, Office Based Aesthetic Medicine, Skin Rejuvenation, Techniques & Methods, Techniques & Methods for Fat Harvesting, Processing & Grafting

October 2013 Drs. Tonnard and Verpaele published a study titled “Nanofat Grafting: Basic Research and Clinical Applications” in Plastic and Reconstructive Surgery. The study evaluated the cellular contents of Nanofat and its efficacy in clinical applications which “showed remarkable improvements in skin quality 6 months postoperatively.” Click below to read the full study.