Category: Ideas & Innovations

Effects of Nanofat and PRP on Type I Collagen Production in Striae Distensae: Preliminary Findings from a Prospective, Randomized Single-Blind Study

Posted in Breast, Buttock, Clinical Trials & Pilot Studies, Dermatology, Facial Rejuvenation & Skin Quality, Ideas & Innovations, Office Based Aesthetic Medicine, Plastic Surgery, Scar Treatment, Skin Scars & Acne Scarring

Date Published: 03 December 2024 La Padula et al. evaluate the effects of nanofat and platelet-rich plasma on type I collagen production in striae distensae, demonstrating enhanced collagen synthesis and suggesting their potential as regenerative treatment options. The article was published in the Aesthetic Plastic Surgery Journal.

Minimally Invasive, Micro-Autologous Fat Transfer for Secondary Occipital Neuralgia

Posted in Clinical Trials & Pilot Studies, Ideas & Innovations, Pain Management

Date Published: 31 October 2025 Pietramaggiori, Peled, et al. evaluate minimally invasive micro-autologous fat transfer for secondary occipital neuralgia, demonstrating improvement in pain symptoms while supporting its potential as a safe and effective treatment option. The article was published in Pain Practice.

Can the Autogenous Nanofat Injection Improve the Symptoms of Patients With Temporomandibular Joint Internal Derangement? A Prospective Observational Clinical Study

Posted in Clinical Trials & Pilot Studies, Craniofacial, Ideas & Innovations, Orthopedics, Plastic Surgery, TMJ

Date Published: 13 Nov 2023 Ali et al. evaluate the effectiveness of intra-articular nanofat injection for temporomandibular joint internal derangement, demonstrating improvements in pain, mouth opening, and joint sounds while supporting its potential as a minimally invasive treatment option. The article was published in the The Journal of Craniofacial Surgery.

Assessment of Therapeutic Effect of Intra-Articular Nanofat Injection for Temporomandibular Disorders

Posted in Clinical Trials & Pilot Studies, Craniofacial, Ideas & Innovations, Orthopedics, TMJ

Date Published: May/June 2019 Mahmmood et al. report that intra‑articular nanofat injection in patients with temporomandibular disorders was safe, well‑tolerated, suggesting therapeutic benefit as a minimally invasive treatment option. The article was published in the Journal of Craniofacial Surgery.

Can nano-fat injection in patients with tempromandibular disorder alters salivary matrix metalloproteinases 2 and 9?

Posted in Clinical Trials & Pilot Studies, Craniofacial, Ideas & Innovations, Orthopedics, TMJ

Date Published: 10 January 2024 Jafar & Hadi report that nano‑fat injections in patients with temporomandibular disorder significantly reduce salivary matrix metalloproteinases 2 and 9 levels, suggesting a potential therapeutic effect on extracellular matrix remodeling in TMD. The article was published in the Multidisciplinary Science Journal.

Intra-Articular Injection of Adipose-Derived Stromal Vascular Fraction in Osteoarthritic Temporomandibular Joints: Study Design of a Randomized Controlled Clinical Trial

Posted in Clinical Trials & Pilot Studies, General Orthopedics, Ideas & Innovations, Orthopedics, TMJ

Date Published: 10 February 2024 Schipper et al. investigate intra-articular injection of adipose-derived stromal vascular fraction for osteoarthritic temporomandibular joints, aiming to evaluate its safety and efficacy as a regenerative treatment approach. The article was published in Bioengineering.

Clarification of the Concept of “Regeneration” in the Context of Calcium Hydroxylapatite and Its Promotion in Regenerative Aesthetics

Posted in Aesthetic Dermatology (Facial Volume Restoration), Facial Rejuvenation & Skin Quality, Facial Volume Restoration, Ideas & Innovations, Latest News, Skin Rejuvenation

Date Published: 22 October 2025 Tonnard, Verpaele, & Romero discuss the use of the term regeneration in aesthetic medicine, emphasizing that treatments like Calcium Hydroxylapatite primarily promote tissue remodeling rather than true biological regeneration and highlight the need for more precise terminology in the field. The article was published in the Aesthetic Surgery Journal.

Fat embolism syndrome: a review in cosmetic surgery

Posted in Facial Surgery, Facial Volume Restoration, Ideas & Innovations, Latest News, Office Based Aesthetic Medicine, Plastic Surgery, Techniques & Methods for Fat Harvesting, Processing & Grafting

Date Published: 30 August 2024 Kim, et al. investigate fat embolism syndrome, an associated side effect of liposuction and fat grafting procedures, and identify effective treatment options based on the subtypes of this condition. The article was published in the Kosin Medical Journal.

The Regenerative Marriage Between High-Density Platelet-Rich Plasma and Adipose Tissue

Posted in AD-cSVF, AD-tSVF, AD-MSC, Basic Science & Research, Ideas & Innovations, Latest News, PRP & Adipose, Regenerative Potential & Mechanisms of Nanofat, Wound Healing

Date Published: 27 February 2025 Everts et al., investigate the synergistic effects of combining HD-PRP with adipose tissue, particularly looking at the role of t-SVF in these effects. They find that the combination multicellular approach using both of these cellular biological products leads to improved tissue repair, regeneration and, wound healing. The article was published […]

Autologous lipoaspirate as a new treatment of vulvar lichen sclerosus: A review on literature

Posted in Clinical Trials & Pilot Studies, Gynecology & Female Sexual Wellness, Ideas & Innovations

Date Published: 11 March 2022 Nanouk van der Sluis et al., complete a review of pioneering studies already done to investigate the therapeutic effect of adipose tissue grafting for Lichen Sclerosus. In this review, they provide an overview of these studies and the proposed mechanisms-of-action of using fat grafting to treat LS. The article was published […]

Discussion: Protein profiling of mechanically processed lipoaspirates: Discovering wound healing and antifibrotic biomarkers in nanofat

Posted in Basic Science & Research, Ideas & Innovations, Regenerative Potential & Mechanisms of Nanofat

November 2021 Dr. Ramon Llull wrote this discussion titled “Discussion: Protein profiling of mechanically processed lipoaspirates: Discovering wound healing and antifibrotic biomarkers in nanofat” in Plastic and Reconstructive Surgery. Click below to read the full article.

Impact of Aging on the Regenerative Properties of Bone Marrow, Muscle & Adipose-Derived Mesenchymal

Posted in AD-cSVF, AD-tSVF, AD-MSC, Basic Science & Research, Ideas & Innovations

January 22nd, 2019 Olivia S. Beane, Vera C. Fonseca, Leroy L. Cooper, Gideon Koren, and Eric M. Darling look at the effects of aging on the regenerative properties of bone marrow-, muscle-, and adipose-derived mesenchymal stem/ stromal cells. The article was published in PLOS ONE. Want to learn more about this topic? Visit the SDARTs […]