Scientific Articles

First live births after adipose-derived stem cells and platelet-rich plasma intraovarian administration

Posted in Clinical Trials & Pilot Studies, Gynecology & Female Sexual Wellness, Ideas & Innovations, Latest News, PRP & Adipose

Date Published: 30 December 2025 Merhi et al. evaluate intraovarian injection of nanofat combined with platelet-rich plasma as a novel treatment for diminished ovarian reserve, demonstrating successful pregnancies in women with prior IVF failure and suggesting this approach as a promising fertility-restoring option. The article was published in the American Journal of Stem Cells.

Nanofat for Injection Laryngoplasty: A Preliminary Study of a New Substrate

Posted in Clinical Trials & Pilot Studies, ENT / Laryngology

Date Published: 11 February 2025 Gidumal et al. evaluate nanofat injection laryngoplasty as a novel treatment for vocal fold atrophy, demonstrating significant improvement in voice function and voice quality with nanofat comparable or superior to microfat, and suggesting nanofat as a promising alternative for vocal atrophy augmentation. The article was published in Journal of Voice.

Adding Nanofat to Fat Grafting to Treat Velar Scarring in Velopharyngeal Incompetence

Posted in Clinical Trials & Pilot Studies, Craniofacial, ENT / Laryngology, Plastic Surgery

Date Published: 23 April 2020 Cantarella et al. evaluate adding nanofat to traditional fat grafting for treatment of velar scarring in velopharyngeal incompetence, reporting that nanofat’s regenerative properties may improve velar scar elasticity and pliability and suggesting it as a promising adjunct to enhance outcomes in mild VPI. The article was published in the Journal […]

Augmentation of Scarred Vocal Folds With Centrifuged and Emulsified Autologous Fat Grafts

Posted in Clinical Trials & Pilot Studies, Craniofacial, ENT / Laryngology, Plastic Surgery

Date Published: 23 June 2020 Salmerón-González et al. evaluate the use of centrifuged and emulsified autologous fat grafts for the treatment of scarred vocal folds and demonstrate improved vocal fold function and mucosal wave characteristics, suggesting this technique as a promising regenerative approach for vocal fold scarring. The article was published in Otolaryngology–Head and Neck […]

Management of Vocal Fold Scars by Concurrent Nanofat and Microfat Grafting

Posted in Clinical Trials & Pilot Studies, ENT / Laryngology

Date Published: 21 November 2018 Cantarella et al. evaluate the use of concurrent nanofat and microfat grafting for the treatment of vocal fold scars, demonstrating improved vocal fold pliability and functional outcomes and suggesting this combined regenerative approach as a promising therapeutic option. The article was published in Journal of Craniofacial Surgery.

Autologous Fat Grafting for the Treatment of Mild to Moderate Velopharyngeal Insufficiency

Posted in Clinical Trials & Pilot Studies, Craniofacial, ENT / Laryngology, Plastic Surgery

Date Published: 31 December 2018 Adams et al. evaluate the effectiveness of autologous fat grafting for treating mild to moderate velopharyngeal insufficiency following cleft palate surgery, demonstrating improved speech outcomes in most patients with no reported complications and suggesting it as a safe, minimally invasive therapeutic option. The article was published in the Journal of […]

49. Flow Cytometric Analysis of Adipose-derived Stromal Vascular Fraction Harvested Using Two Common Liposuction Cannula From Different Donor Sites in Autologous Fat Graft Surgery

Posted in AD-cSVF, AD-tSVF, AD-MSC, Basic Science & Research, Ideas & Innovations, Office Based Aesthetic Medicine, Techniques & Methods, Techniques & Methods for Fat Harvesting, Processing & Grafting

Date Published: 16 May 2025 Shams et al. report that stromal vascular fraction harvested from adipose tissue varies in cellular composition depending on the liposuction cannula type and donor site. These findings suggest that both harvesting technique and anatomical source may influence the regenerative potential of fat grafts in autologous fat graft surgery. The article […]

Effects of Nanofat and PRP on Type I Collagen Production in Striae Distensae: Preliminary Findings from a Prospective, Randomized Single-Blind Study

Posted in Breast, Buttock, Clinical Trials & Pilot Studies, Dermatology, Facial Rejuvenation & Skin Quality, Ideas & Innovations, Office Based Aesthetic Medicine, Plastic Surgery, Scar Treatment, Skin Scars & Acne Scarring

Date Published: 03 December 2024 La Padula et al. evaluate the effects of nanofat and platelet-rich plasma on type I collagen production in striae distensae, demonstrating enhanced collagen synthesis and suggesting their potential as regenerative treatment options. The article was published in the Aesthetic Plastic Surgery Journal.

Minimally Invasive, Micro-Autologous Fat Transfer for Secondary Occipital Neuralgia

Posted in Clinical Trials & Pilot Studies, Ideas & Innovations, Pain Management

Date Published: 31 October 2025 Pietramaggiori, Peled, et al. evaluate minimally invasive micro-autologous fat transfer for secondary occipital neuralgia, demonstrating improvement in pain symptoms while supporting its potential as a safe and effective treatment option. The article was published in Pain Practice.

Can the Autogenous Nanofat Injection Improve the Symptoms of Patients With Temporomandibular Joint Internal Derangement? A Prospective Observational Clinical Study

Posted in Clinical Trials & Pilot Studies, Craniofacial, Ideas & Innovations, Orthopedics, Plastic Surgery, TMJ

Date Published: 13 Nov 2023 Ali et al. evaluate the effectiveness of intra-articular nanofat injection for temporomandibular joint internal derangement, demonstrating improvements in pain, mouth opening, and joint sounds while supporting its potential as a minimally invasive treatment option. The article was published in the The Journal of Craniofacial Surgery.

Assessment of Therapeutic Effect of Intra-Articular Nanofat Injection for Temporomandibular Disorders

Posted in Clinical Trials & Pilot Studies, Craniofacial, Ideas & Innovations, Orthopedics, TMJ

Date Published: May/June 2019 Mahmmood et al. report that intra‑articular nanofat injection in patients with temporomandibular disorders was safe, well‑tolerated, suggesting therapeutic benefit as a minimally invasive treatment option. The article was published in the Journal of Craniofacial Surgery.

Can nano-fat injection in patients with tempromandibular disorder alters salivary matrix metalloproteinases 2 and 9?

Posted in Clinical Trials & Pilot Studies, Craniofacial, Ideas & Innovations, Orthopedics, TMJ

Date Published: 10 January 2024 Jafar & Hadi report that nano‑fat injections in patients with temporomandibular disorder significantly reduce salivary matrix metalloproteinases 2 and 9 levels, suggesting a potential therapeutic effect on extracellular matrix remodeling in TMD. The article was published in the Multidisciplinary Science Journal.